Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak incidence in the 5th decade of life, affecting women more than men. Its clinical presentation involves watery diarrhea in the absence of rectal bleeding. It is often classified under the umbrella entity microscopic colitis, that it shares with a related condition, lymphocytic colitis.
Video Collagenous colitis
Signs and symptoms
Microscopic colitis causes chronic watery diarrhea with greater than 10 bowel movements per day. Some patients report nocturnal diarrhea, abdominal pain, urgency, fecal incontinence, fatigue, dehydration and weight loss. Patients report a significantly diminished quality of life.
Maps Collagenous colitis
Causes
The cause of collagenous colitis is unknown.
Diagnosis
On colonoscopy, the mucosa of the colon typically looks normal, but biopsies of affected tissue usually show deposition of collagen in the lamina propria, which is the area of connective tissue between colonic glands. Radiological tests, such as a barium enema are also typically normal.
Treatment
Treatment of collagenous colitis is often challenging. Typically, one or more of the following therapeutic agents are used:
- Bismuth agents, including Pepto-Bismol
- 5-aminosalicylic acid
- Budesonide
- Immunosuppressants, including azathioprine
- Corticosteroids
Pilot-scale studies have shown some evidence of possible benefit for both Boswellia serrata extract and specific strains of probiotics in the treatment of collagenous colitis, although larger sample sizes are needed to confirm the results.
See also
- Colitis
- Lymphocytic colitis
- Inflammatory bowel disease
- Ulcerative colitis
References
Personal experience with collagenous colitis
- Chande N, Driman DK, Reynolds RP (March 2005). "Collagenous colitis and lymphocytic colitis: patient characteristics and clinical presentation". Scand. J. Gastroenterol. 40 (3): 343-7. doi:10.1080/00365520510011623. PMID 15932175.
- Yen E. F.; Pardi D. S. (May 2011). "Microscopic Colitis - Lymphocytic, Collagenous and 'Mast Cell' Colitis". Alimentary Pharmacology & Therapeutics. 34 (1): 21-32. doi:10.1111/j.1365-2036.2011.04686.x.
- Majores Michael; Wunsch Steffen; Blume Bernd; Fischer Hans-Peter & Reichel Christoph (October 2011). "Mucosal Atrophy in Collagenous Colitis: A Case Report". 11 (114). doi:10.1186/1471-230X-11-114.
- Milman Nataliya; Kraa Gunnar (2010). "NSAID-induced Collagenous Colitis". The Journal of Rheumatology. 37 (11): 2432-243. doi:10.3899/jrheum.100573.
Source of the article : Wikipedia
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